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Australian Adverse Drug Reactions Bulletin

The Australian Adverse Drug Reactions Bulletin is produced six times a year by the Adverse Drug Reactions Advisory Committee.

Australian Adverse Drug Reactions Bulletin 2008

  • Volume 27, Number 5 (October 2008)
    Fatal interactions and reactions with colchicine: beware CYP3A4 inhibitors
    Fluoroquinolone antibiotics and tendon disorders: still a problem
    Drug-induced hyponatraemia
  • Volume 27, Number 4 (August 2008)
    New "Blue card" reporting form for ADRs
    High-dose vitamin B6 may cause peripheral neuropathy
    Desmopressin and hyponatraemia
  • Volume 27, Number 3 (June 2008)
    Severe skin reactions and venous thromboembolism with strontium ranelate (Protos)
    Statins and muscle disorders - be careful with the dose
    Hepatic toxicity with nitrofurantoin
  • Volume 27, Number 2 (April 2008)
    Nicorandil-associated ulceration
    Withdrawal of lumiracoxib in Australia
    Topiramate and other drugs causing glaucoma
  • Volume 27, Number 1 (February 2008)
    MRI scans with gadolinium-containing contrast agents and the risk of NSF - caution in patients with renal impairment
    Hepatic reactions with terbinafine
    Interaction between glucosamine and warfarin

Australian Adverse Drug Reactions Bulletin 2007

  • Volume 26, Number 6 (December 2007)
    Emerging cardiovascular concerns with rosiglitazone
    Erythropoietins: aim for lower haemoglobin levels
    Reports of hypersensitivity reactions to pregabalin
    Transdermal medications - look for the patch
  • Volume 26, Number 5 (October 2007)
    Thiazolidinediones and reduced bone density
    Renal impairment with zoledronic acid
    Dangers associated with chronic ingestion of colloidal silver
  • Volume 26, Number 4 (August 2007)
    Rituximab and progressive multifocal leukoencephalopathy
    Implanon: interactions and failure of contraception
    Atypical antipsychotic agents and extrapyramidal side effects
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  • Volume 26, Number 3 (June 2007)
    Clozapine and myocarditis
    Mirtazapine and blood dyscrasias
    Black cohosh and liver toxicity - an update
    ADRAC celebrates 300 Meetings
  • Volume 26, Number 2 (April 2007)
    Aripiprazole and neuroleptic malignant syndrome
    Varicella vaccine experience in Australia
    Drugs of current interest
  • Volume 26, Number 1 (February 2007)
    Traditional Indian (Ayurvedic) and Chinese medicines associated with heavy metal poisoning
    Zolpidem and bizarre sleep related effects
    Increased risk of fractures associated with enzyme-inducing antiepileptic medicines

Australian Adverse Drug Reactions Bulletin 2006

  • Volume 25, Number 6 (December 2006)
    Drug induced pancreatitis
    Leflunomide and interstitial lung disease
    Tumour necrosis factor alpha inhibitors
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  • Volume 25, Number 5 (October 2006)
    Beware the triple whammy!
    Leflunomide and peripheral neuropathy
    Ezetimibe and depression - A possible signal
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  • Volume 25, Number 4 (August 2006)
    Osteonecrosis of the jaw with bisphosphonates
    Dose reduction of LMWH (enoxaparin) in chronic kidney disease
    Life threatening blood dyscrasias with oral terbinafine
  • Volume 25, Number 3 (June 2006)
    Problems with colloids in fluid resuscitation
    Reactivation of hepatitis B virus following cytotoxic or immunosuppressant therapy
    Sibutramine - Four years experience
  • Volume 25, Number 2 (April 2006)
    Hepatotoxicity with black cohosh
    Medical Alert devices
    Interactions with macrolides
    Changes to ADRAC membership
  • Volume 25, Number 1 (February 2006)
    Deaths with galantamine in mild cognitive impairment studies
    Fluoroquinolone antibiotics
    ...Interactions with warfarin
    ...Remember tendon disorders
    Ergot derivatives and fibrotic reactions

Australian Adverse Drug Reactions Bulletin 2005

  • Volume 24, Number 6 (December 2005)
    Medicines and QT prolongation
    Skin reactions with glucosamine
    Warfarin-induced skin necrosis
  • Volume 24, Number 5 (October 2005)
    Inadvertent paracetamol overdose
    Please report paediatric adverse reactions
    Screening guidelines for women exposed to DES in utero
    Retirement of Dr John McEwen
  • Volume 24, Number 4 (August 2005)
    Suicidality with SSRIs: adults and children
    Ezetimibe and muscle disorders
    Pathological gambling with cabergoline
    Reporting problems with products other than medicines
  • Volume 24, Number 3 (June 2005)
    Acne, isotretinoin and suicidality
    Genitourinary symptoms with reboxetine
    The multiple toxicities of amiodarone
    Antidepressants in children and adolescents
    Pimecrolimus, skin cancer and lymphoma
  • Volume 24, Number 2 (April 2005)
    Statins and peripheral neuropathy
    Avascular necrosis with interferon alfa-2b in CML
    Angioedema - still a problem with ACE inhibitors
    Evidence-based medicine: pitfalls of overlooking safety
  • Volume 24, Number 1 (February 2005)
    Adverse reactions to complementary medicines
    Avoiding fetal abnormalities with isotretinoin
    Bisphosphonates and osteonecrosis of the jaw
    Statins contraindicated in pregnancy

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Australian Adverse Drug Reactions Bulletin 2004

  • Volume 23, Number 6 (December 2004)
    Use of SSRI antidepressants in children and adolescents
    Cardiovascular risk with the selective COX-2 inhibitors
    Propofol: danger of prolonged and high infusion rates in ICU
  • Volume 23, Number 5 (October 2004)
    Australian experience with pneumococcal conjugate vaccine
    Warnings for high dose tricyclic antidepressants
    Terbinafine and blood dyscrasias
    Cholinesterase inhibitors and cardiac arrhythmias
    Quinine indications - cramps deleted
  • Volume 23, Number 4 (August 2004)
    Cardiac valvulopathy with pergolide
    Clopidogrel - haemorrhage and haematological disorders
    Pulmonary toxicity with long-term nitrofurantoin
    Tramadol-warfarin interaction
  • Volume 23, Number 3 (June 2004)
    The legacy of diethylstilboestrol (DES) from the 50s and 60s
    Parecoxib - one shot only
    Corticosteroids should be used with long-acting ß2-agonists
    Atypical antipsychotics and hyperglycaemia
  • Volume 23, Number 2 (April 2004)
    The risks and benefits of HRT
    Macrolides and warfarin interaction
    Bisphosphonates and ocular inflammation
    SSRI antidepressants in children and adolescents
  • Volume 23, Number 1 (February 2004)
    Risk factors for myopathy and rhabdomyolysis with the statins
    High dose cyproterone and hepatotoxicity
    Serotonin syndrome

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Australian Adverse Drug Reactions Bulletin 2003

  • Volume 22, Number 6 (December 2003)
    Meningococcal C vaccine: early experience is reassuring
    Harmful interactions
    Post-partum NSAIDs may cause hypertension
  • Volume 22, Number 5 (October 2003)
    Rofecoxib, celecoxib and cardiovascular risk
    Convulsions and blood dyscrasias with mirtazapine
    Anti-epileptic drugs, pregnancy and fetal malformations
    Hormone replacement therapy
  • Volume 22, Number 4 (August 2003)
    Maternal SSRI use and neonatal effects
    ACE inhibitor, diuretic and NSAID: a dangerous combination
    Serious gastrointestinal effects with celecoxib and rofecoxib
    Travacalm - your reports make a difference!
  • Volume 22, Number 3 (June 2003)
    Hyponatraemia with SSRIs
    Pregnancy despite depot medroxyprogesterone
    Hepatic reactions with minocycline
    Implanon and vaginal bleeding
  • Volume 22, Number 2 (April 2003)
    Fluticasone and adrenal crisis
    The glitazones - early experience
    Interstitial nephritis with the proton pump inhibitors
    Interactions with grapefruit juice - amendment
  • Volume 22, Number 1 (February 2003)
    Tramadol - four years' experience
    Minocycline and not so benign intracranial hypertension
    Acute neuropsychiatric events with celecoxib and rofecoxib
    Linezolid and peripheral neuropathy
    Kava

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Australian Adverse Drug Reactions Bulletin 2002

  • Volume 21, Number 4 (December 2002)
    Interactions with grapefruit juice
    Miconazole oral gel elevates INR - a reminder
    Fluoroquinolones and tendon disorders
    Online reporting of adverse reactions - coming soon
  • Volume 21, Number 3 (August 2002)
    Patent blue V and anaphylaxis
    Quinine and profound thrombocytopenia
    Indapamide and hyponatraemia
    Epoetin alfa and pure red cell aplasia
  • Volume 21, Number 2 (June 2002)
    Sildenafil - three years experience
    Haemorrhagic cystitis with ticarcillin in cystic fibrosis patients
    Venous thromboembolism with third generation oral contraceptives and cyproterone
  • Volume 21, Number 1 (February 2002)
    Electrolyte disturbances with sodium picosulfate bowel cleansing products
    Amiodarone and pulmonary toxicity
    Interaction of rofecoxib with warfarin
    Seeing things with zolpidem

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Australian Adverse Drug Reactions Bulletin 2001

  • Volume 20, Number 2 (June 2001)
    Update on bupropion (Zyban SR)
    Leflunomide: serious hepatic, blood, skin and respiratory reactions
  • Volume 20, Number 1 (February 2001)
    Interaction of celecoxib and warfarin
    Metformin and lactic acidosis - a reminder
    Cerivastatin and rhabdomyolysis - avoid gemfibrozil
    SSRIs and increased intraocular pressure
    Warning: potential for confusion with Humalog

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Australian Adverse Drug Reactions Bulletin 2000

  • Volume 19, Number 4 (December 2000)
    Restriction of indications for cisapride
    Interaction between ergotamine and erythromycin
    Methysergide and cardiac valvulopathy
  • Volume 19, Number 3 (August 2000)
    Drug interactions and adverse drug reactions
    Cyclosporin and St John's wort: CYP3A4
    Simvastatin and nefazodone: CYP3A4
    Perhexiline and paroxetine: CYP2D6
    Fluvoxamine and warfarin: CYP1A2
  • Volume 19, Number 2 (June 2000)
    Celecoxib: early Australian reporting experience
    Zanamivir and respiratory effects
    Alert! Interactions with St John's wort
    Valaciclovir: renal impairment and neuropsychiatric reactions
  • Volume 19, Number 1 (February 2000)
    Drug-induced nightmares
    Take care with vitamin K
    Problems with caffeine
    Allopurinol azathioprine interaction - a reminder
    New drug update - leflunomide

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Australian Adverse Drug Reactions Bulletin 1999

  • Volume 18, Number 2 (June 1999)
    Depression with interferon
    Coumadin and Marevan are not interchangeable
    Drug-induced gingival overgrowth
    A comparison of dicloxacillin with flucloxacillin
  • Volume 18, Number 1 (February 1999)
    Angiotensin II receptor antagonists ? new drugs ...
      ... with some old problems
      ... and some new problems
    Allergic reactions with echinacea
    Update on visual field constriction with vigabatrin
    Withdrawal of tolcapone

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Australian Adverse Drug Reactions Bulletin 1998

  • Volume 17, Number 2 (May 1998)
    Ticlopidine update
    Protease inhibitors
    Methotrexate - name the day
    Interaction between miconazole oral gel and warfarin
  • Volume 17, Number 1 (February 1998)
    Paradoxical reactions with midazolam in children
    Venlafaxine: not just an SSRI?
    Depression - could it be the drug?
    Withdrawal of fenfluramine and dexfenfluramine

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Australian Adverse Drug Reactions Bulletin 1997

  • Volume 16, Number 4 (November 1997)
    SSRIs and neonatal disorders ......
    ...... Withdrawal reactions
    ...... Breast milk transfer
    Boxed warnings
    Laboratory monitoring with calcitriol - an update
    Fatal outcomes after sumatriptan
  • Volume 16, Number 3 (August 1997)
    Alendronate oesophagitis - are precautions effective?
    Pethidine and convulsions
    Drug-induced gynaecomastia
    Visual field defects with vigabatrin
  • Volume 16, Number 2 (May 1997)
    Kombucha tea
    Clozapine induced neuroleptic malignant syndrome
    The Achilles heel of fluoroquinolones
    Paraesthesia with NSAIDS
  • Volume 16, Number 1 (February 1997)
    Electrolyte disturbances with oral phosphate bowel preparations
    Calcitriol and hypercalcaemia
    Fluvastatin and muscle disorders - a class effect
    Lamotrigine and severe skin reactions

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Australian Adverse Drug Reactions Bulletin 1996

  • Volume 15, Number 4 (November 1996)
    Minocycline and ...... the liver, the CNS, the skin
    Vitamin A and birth defects
    Angioedema and ACE inhibitors
    Moclobemide and hypertension is it drug-induced?
  • Volume 15, Number 3 (August 1996)
    Cisapride and cardiac arrhythmias
    Oral acyclovir and neurological reactions
    SSRIs and genitourinary disorders
  • Volume 15, Number 2 (May 1996)
    Drug-induced liver disease ...
    ... Antibiotics of continuing concern
    Hepatitis B vaccines - musculoskeletal reactions
  • Volume 15, Number 1 (February 1996)
    Quinine and haemolytic uraemic syndrome
    Terbinafine - a question of taste
    SSRIs and withdrawal syndrome
    Possible arrhythmias due to loratadine? - More help please

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Australian Adverse Drug Reactions Bulletin 1995

  • Volume 14, Number 4 (November 1995)
    Nitrofurantoin and the lung
    Omeprazole...
    ... and musculoskeletal problems
    ... and interstitial nephritis
    Drug-induced pancreatitis
  • Volume 14, Number 3 (August 1995)
    Cefaclor in the young patient: arthritis and arthralgia
    Simvastatin and adverse endocrine effects in men
    Lodema and the liver
    Interaction of warfarin with macrolide antibiotics

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